The design and functional complexity of medical devices and systems has increased during the past half century, evolving from cardiac pacemakers to magnetic resonance imaging. Such life-saving advancements are monumentally advantageous, but with so much at stake, a step-by-step manual for biomedical engineers is essential. This second edition of a bestselling textbook utilizes a strong design perspective to provide designers with a thorough overview of the field, including topics related to databases, process analysis, and device improvement.